Once at the gates of the facility, NRL is an additional 5-7 minute drive. is a service of the American Association for the Advancement of Science. NRL is a scientific and engineering command dedicated to research that drives innovative advances for the Navy and Marine Corps from the seafloor to space and in the information domain. h�b```a``*a`b`ش�A�������c �E��G))E2��Jp4@ \����H�1;H�Q�A h� ��9�p!� Qa6'�,�h6� ���X�� ��``���*�0 �{f All participants must be U.S. citizens. "While we had some idea that this was possible, the extent to which this occurred with very low amounts of quantum dot pseudo-virions suggested we had a powerful system to track viral attachment and effects on the cell in real time, since these quantum dots are fluorescent," said Gorshkov. EurekAlert! Human Resources Coordinator "We refer to these probes as 'Pseudo-virions' because they approximate the shape of the SARS-CoV-2 virus while also mimicking their physiological interactions with human cells," said Wolak. view more, Credit: National Center for Advancing Translational Sciences. Code 1810 Building 72 North This results in conditions that are ripe for rapid and extensive outbreaks, such as the one reported on the USS Theodore Roosevelt, which threaten mission success.". Select a program for more information and learn how to apply for each one. "Protecting the health of deployed warfighters is of the utmost importance to ensure mission readiness and maintain fleet readiness," said Wolak. The nanoparticle probes developed at NRL are comprised of multiple Spike protein subunits attached to the surface of a light-emitting quantum dot core. EurekAlert! As the Navy’s full-spectrum corporate laboratory, NRL conducts a broadly based, multidisciplinary program of scientific research and advanced technological development directed toward maritime applications of new and improved materials; techniques; equipment; systems; ocean, atmospheric, and space sciences; and related technologies. "By forging these strong relationships, we can synergize our efforts and come to novel solutions from completely different perspectives and viewpoints.". are not responsible for the accuracy of news releases posted to EurekAlert! The NRL/NCATS team also plans to explore the possibility of using the pseudo-virions for site-specific intracellular drug delivery for purposes of disrupting SARS-CoV-2 replication mechanisms. Naval Research Laboratory and National Center for Advancing Translational Sciences (NCATS), submitted their findings to ACS Nano, a monthly peer-reviewed scientific journal, on their collaboration to develop SARS-CoV-2 nanoparticle probes that are used to study fundamental interactions between SARS-CoV-2 Spike proteins and human cells.
NRL is a scientific and engineering command dedicated to research that drives innovative advances for the Navy and Marine Corps from the seafloor to space and in the information domain. The National Suicide Prevention Lifeline is a national network of local crisis centers that provides free and confidential emotional support to people in suicidal crisis or emotional distress 24 hours a …

"The ultimate goals of the collaboration are to clarify the fundamental mechanisms by which SARS-CoV-2 causes infection and to screen and identify potential drugs to inhibit these mechanisms.". "This also opened the door for high-throughput testing of new drugs uncovered by the other approaches at NCATS, to cross-validate the compounds with our system, and to test completely new therapeutic modalities developed at NCATS and elsewhere both biochemically at NRL, and in cell-based assays at NCATS," said Gorshkov. Space systems technology, development, and support. NRL is located in Washington, D.C., with major field sites in Stennis Space Center, Mississippi; Key West, Florida; and Monterey, California, and employs approximately 2,500 civilian scientists, engineers and support personnel. h��T�o�0�W��vlj4Mj�
%PDF-1.5 %����

Wolak said, "It is very important to note that the Spike-containing pseudo-virion has potential for broad application of intracellular drug delivery to combat not only COVID19, but any disease that targets cells with ACE2 receptors.". ProSource360 Consulting Services Inc. 1215 17th Street, NW Suite 400 703-300-4836 - Office 202-315-2556 - Fax ONRPrograms@Prosource360.comONRPrograms@Prosource360.com The Naval Research Laboratory (NRL) is the US Navy corporate laborator y, dedicated to addressing Navy unique problems and enabling the N avy to operate efficien tly and safely. Additional questions may be directed to the NRL Human Resources Office at (202) 767-3031. The manuscript, accepted on Aug. 18, is titled "Quantum Dot-Conjugated SARS-CoV-2 Spike Pseudo-Virions Enable Tracking of Host Cell Surface Angiotensin Converting Enzyme 2 Binding and Endocytosis."