epidermal growth factor receptor cancer


The epidermal growth factor receptor (EGFR) and other members of the EGFR/ErbB receptor family of receptor tyrosine kinases (RTKs) are important regulators of proliferation, angiogenesis, migration, tumorigenesis and metastasis.
11, 1911–1914 (2001). Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung.

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EGFR

Pao, W. et al. 15, 3249–3262 (2001). Cappuzzo, F. et al. Inukai, M. et al. Amplification of the EGFR gene and mutations of the EGFR tyrosine kinase domain have been recently demonstrated to occur in carcinoma patients. 11, 5878–5885 (2005). Wedge, S. R. et al. 58, 594–600 (2006). Hurbin, A., Dubrez, L., Coll, J. L. & Favrot, M. C. Inhibition of apoptosis by amphiregulin via an insulin-like growth factor-1 receptor-dependent pathway in non-small cell lung cancer cell lines. These trans-membrane proteins are activated following binding with peptide growth factors of the EGF-family of proteins. Singh, J. et al. Kwak, E. L. et al. & Moasser, M. M. Resistance to gefitinib in PTEN-null HER-overexpressing tumor cells can be overcome through restoration of PTEN function or pharmacologic modulation of constitutive phosphatidylinositol 3′-kinase/Akt pathway signaling. Epidermal growth factor receptor mutations in lung cancer The development and clinical application of inhibitors that target the epidermal growth factor receptor (EGFR) provide important insights for new lung cancer therapies, as well as for the broader field of targeted cancer therapies. Cancer 116, 36–44 (2005). Clin. Cancer Res. Jpn J. Clin. 23, 857–865 (2005). Shigematsu, H. & Gazdar, A. F. Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers. Mutations of epidermal growth factor receptor of non-small cell lung cancer were associated with sensitivity to gefitinib in recurrence after surgery. Janne, P. A., Engelman, J. 65, 3336–3346 (2005).

Chemotherapy can prolong survival in patients with advanced non-small-cell lung cancer — report of a Canadian multicenter randomized trial. Mol. 62, 5749–5754 (2002). Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis. Sci. Bioorg. Oncol. Lett. 12, 4446s–4450s (2006). ISSN 1474-1768 (online). Non-small-cell lung cancer and Ba/F3 transformed cells harboring the ERBB2 G776insV_G/C mutation are sensitive to the dual-specific epidermal growth factor receptor and ERBB2 inhibitor HKI-272. Mol. Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib. New approaches to anticancer target discovery.