Much to Kenny's delight, Lee activates the controls on in front of the engineer's chair. She is hesitant to part with her hair, but Lee makes the final decision to cut it. Kenny barely manages to keep standing at Duck's death. He shouts for Lilly to get down there before they left without her. He offers to do anything to stay with the group, but Lilly just sees this as a sign that he is guilty.

Lee then proceeds to the locomotive cab to try and convince Kenny that he needs to stop the train and deal with his son. (Determinant). (Determinant) Lilly then points to Ben and threatens to kick him out of the group, then asks for the others' opinions on what to do with him. Ben spots a massive zombie herd heading toward the group, and they must leave, as Omid finally cuts the coupling. When ready, the group boards the train and begin to make their way to Savannah. Lee offers a response to which Kenny curtly spits on. Her lines are in audio clips. He bluntly states that somebody else needs to think about the food situation and the protection of the motel and what happens when the motel needs to be abandoned. Lee finds a blowtorch in the station, but a locked gate separates him from the object. If Lee kills the walker with the car door without looking at the animal crackers box, then chooses to do so, the walker's legs will phase back over it as if it were still kicking. He also tries to leave Lee behind or helps save his life when Lee is crushed by a door in the drugstore. A third successful move from either man ends the fight, regardless of what had happened between the start of the fight and then. Lee can either aggressively crush Kenny's windpipe or gently keep him from hurting himself. For The Walking Dead: Episode 5 - No Time Left on the PlayStation 3, a GameFAQs Q&A question titled "Will cutting off his arm ruin anything? Sometimes, a glitch may occur where Lee and Omid are on the bridge, and the bridge itself becomes invisible, making it look as if Lee and Omid are standing twenty-five feet up on nothing. When both of them hit the floor, he sees Clementine shakily holding his pistol on the corpses. If Lee constricts Kenny's throat, then he will either growl about how Kenny was hurting Katjaa and Duck with his actions or that their Lee was starting to regret their friendship depending on their prior relationship. She brings up her belief that someone had been stealing from the group's medicine supply, and mentions that her trust in the others is wearing thin, following which she orders everyone out of her room. After the segment where Lee chose Ducks ultimate fate, the scene cuts to a close shot of the train wheel's, on rare occasions it will stay like this and the only way around it is restarting the game. The survivors spend the last half of the episode on the train recovering and bonding after the many deaths of the original group of survivors. If Lee chooses this option, he can also tell Clementine to meet the two of them there before he dies. Lee notices the bullet in the side of her head and the fallen pistol next to her hand and realizes what Kenny had witnessed. (Determinant) Lee activates the winch, pulling the jeep to meet the trailer. Lilly is the first one out of the RV, scouring the environment and finding a walker trapped beneath the vehicle and caught up in its frame. Kenny asks how the world could let his son live when Kenny had helped put someone else's son in the ground.

Lilly grabs her rifle and orders Lee to go out and distract the invading bandits while she gets herself into a sniping position before climbing out the back window. When both also release the other, they stay standing. Charles says that Lee needs to take better care of Clementine by cutting her hair so that walkers can't grab her easily as well as begin training her on using a gun to which Lee then agrees. Lee and Doug/Carley deal with the remaining bandits, (Determinant) the latter taking the dead bandit's weapon to shoot the others.